TÉCNICAS in vitro PARA AVALIAÇÃO DE POTENCIAIS INIBIDORES DA BOMBA DE EFLUXO NORA EM Staphylococcus aureus: UMA BREVE REVISÃO
DOI:
https://doi.org/10.61164/rsv.v11i1.2814Abstract
The use of antimicrobials revolutionized medicine, but excessive use has led to an increase in antimicrobial resistance (AMR), particularly in bacteria such as Staphylococcus aureus. The NorA protein, an efflux pump from the major facilitator superfamily (MFS), plays a crucial role in bacterial resistance by expelling antimicrobials from the cell, rendering them ineffective. This integrative review analyzes in vitro methodologies for evaluating efflux pump inhibitors (EPIs) that target NorA, highlighting their potential to restore therapeutic efficacy and control infections caused by multidrug-resistant S. aureus
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