TÉCNICAS in vitro PARA AVALIAÇÃO DE POTENCIAIS INIBIDORES DA BOMBA DE EFLUXO NORA EM Staphylococcus aureus: UMA BREVE REVISÃO
DOI:
https://doi.org/10.61164/rsv.v11i1.2814Resumo
O uso de antimicrobianos revolucionou a medicina, mas o uso excessivo tem levado ao aumento da resistência antimicrobiana (RAM), particularmente em bactérias como Staphylococcus aureus. A proteína NorA, uma bomba de efluxo da superfamília dos facilitadores principais (SPF), desempenha um papel crucial na resistência bacteriana ao expelir antimicrobianos do interior celular, tornando-os ineficazes. Esta revisão integrativa analisa metodologias in vitro para avaliar inibidores de bomba de efluxo (EPIs) que atuam sobre a NorA, destacando seu potencial para restaurar a eficácia terapêutica e controlar infecções causadas por S. aureus multirresistente.
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