ATIVIDADE ANTIMICROBIANA DO Zingiber officinale SOBRE DOIS PERIODONTOPATÓGENOS EMERGENTES: UMA REVISÃO DE LITERATURA

Autores/as

  • André Rodrigo Justino da Silva Universidade Estadual da Paraíba
  • Maria Helena Chaves de Vasconcelos Catão Professora Associada, Universidade Estadual da Paraíba, Brasil

DOI:

https://doi.org/10.61164/rmnm.v12i2.3200

Palabras clave:

Zingiber officinale; Doenças periodontais; Fitoterapia.

Resumen

Estudos recentes verificaram a relação entre duas bactérias e a doença periodontal, sendo elas a Klebsiella pneumoniae e Escherichia coli. Estes microrganismos (MO) são tratados como potenciais periodontopatógenos ou “periodontopatógenos emergentes”. O objetivo deste estudo foi realizar uma síntese da literatura acerca do uso do Zingiber officinale contra duas bactérias recentemente associadas à patogênese da doença periodontal: Klebsiella pneumoniae e Escherichia coli. Foi realizado um levantamento bibliográfico nas bases de dados Pubmed/Medline e Scopus para reunir os estudos publicados no período entre 2014 e 2024, sendo incluídos 13 artigos com diferentes metodologias. A Escherichia coli tem sido associada à etiologia da periodontite em estudos que avaliam pacientes brasileiros, além de K. Pneumoniae ter sido encontrada em abundância em pacientes com periodontite não-leve. O agente fitoterápico avaliado apresenta efeito antiinflamatório, controle do sangramento gengival reduzindo a dor pós terapia periodontal básica. Assim, foi possível verificar relação entre Klebsiella pneumoniae e Escherichia coli com a doença periodontal, sendo eficaz o uso de Zingiber officinale no combate destes microorganismos, com resultados apontando níveis positivos de atuação antibiótica/antiinflamatória no mesmo patamar de outras alternativas terapêuticas já estabelecidas e utilizadas para o mesmo fim.

Citas

Abdullah; Hussain, T. et al. Zingiber officinale rhizome extracts mediated ni nanoparticles and its promising biomedical and environmental applications. BMC Complementary Medicine and Therapies. v.23, n.1, p.349, 2023. Disponível em: https://doi.org/10.1186/s12906-023-04182-7.

Aghazadeh, M. et al. Survey of the Antibiofilm and Antimicrobial Effects of Zingiber officinale (in Vitro Study). Jundishapur Journal of Microbiology. v.9, n.2, e30167, 2016. Disponível em: https://doi.org/10.5812/jjm.30167.

Ahmed, N. et al. The Antimicrobial Efficacy Against Selective Oral Microbes, Antioxidant Activity and Preliminary Phytochemical Screening of Zingiber officinale. Infection and Drug Resistance. v.15, p.2773-2785, 2022. Disponível em: https://doi.org/10.2147/IDR.S364175.

Al-Shibani, N. et al. Postoperative Analgesic and Anti-inflammatory Effectiveness of Ginger (Zingiber officinale) and NSAIDs as Adjuncts to Nonsurgical Periodontal Therapy for the Management of Periodontitis. Oral Health &Preventive Dentistry. v.20, n.1, p.227–232, 2022. Disponível em: https://doi.org/10.3290/j.ohpd.b3125633.

Ashour, A. A. et al. Antimicrobial Efficacy of Glass Ionomer Cement in Incorporation with Biogenic Zingiber officinale Capped Silver-Nanobiotic, Chlorhexidine Diacetate and Lyophilized Miswak. Molecules. v.27, n.2, p.528, 2022. Disponível em: https://doi.org/10.3390/molecules27020528.

Chakraborty, B. et al. Bactericidal activity of selected medicinal plants against multidrug resistant bacterial strains from clinical isolates. Asian Pacific Journal of Tropical Medicine. 7S1, S435–S441, 2014. Disponível em: https://doi.org/10.1016/S1995-7645(14)60271-6.

Cordeiro, M. S. F. Desenvolvimento tecnológico e avaliação de estabilidade de gel dermatológico a partir do óleo essencial de gengibre (Zingiber officinale Roscoe). Revista Brasileira de Farmácia. v.94, n.2, p.148-153, 2013.

Elgamily, H.; Safy, R.; Makharita, R. Influence of Medicinal Plant Extracts on the Growth of Oral Pathogens Streptococcus Mutans and Lactobacillus Acidophilus: An In-Vitro Study. Open Access Macedonian Journal of Medical Sciences. v.7, n.14, p.2328-2334, 2019. Disponível em: https://doi.org/10.3889/oamjms.2019.653.

Fiorillo, L. et al. Porphyromonas gingivalis, Periodontal and Systemic Implications: A Systematic Review. Dentistry Journal (Basel). v.7, n.4, p.114, 2019. Disponível em: https://doi.org/10.3390/dj7040114.

Gupta, I. et al. A Preliminary Study on the Evaluation of In-vitro Inhibition Potential of Antimicrobial Efficacy of Raw and Commercial Honey on Escherichia coli: An Emerging Periodontal Pathogen. Mymensingh Medical Journal. v.30, n.2, p.547-554, 2021.

Hernández-Jaimes, T. et al. High Virulence and Multidrug Resistance of Escherichia coli Isolated in Periodontal Disease. Microorganisms. v.11, n.1, p.45, 2022. Disponível em: https://doi.org/10.3390/microorganisms11010045.

Highfield, J. Diagnosis and classification of periodontal disease. Australian Dental Journal.v. 54 Suppl 1, p.11-26, 2009. Disponível em: https://doi.org/10.1111/j.1834-7819.2009.01140.x.

Howshigan, J. et al. The effects of an Ayurvedic medicinal toothpaste on clinical, microbiological and oral hygiene parameters in patients with chronic gingivitis: a double-blind, randomised, placebo-controlled, parallel allocation clinical trial. The Ceylon Medical Journal. v.60, n.4, 126–132, 2015. Disponível em: https://doi.org/10.4038/cmj.v60i4.8219.

Khan, M. et al. A mini-review on the therapeutic potential of Zingiber officinale (ginger). Journal of Natural Products. v.15, p.125, 2019.

Kim, H. S. et al. Raffinose, a plant galactoside, inhibits Pseudomonas aeruginosa biofilm formation via binding to LecA and decreasing cellular cyclic diguanylate levels. Scientific Reports. v.6, p.25318, 2016. Disponível em: https://doi.org/10.1038/srep25318.

Maekawa, L. E. et al. Effect of Zingiber officinale and propolis on microorganisms and endotoxins in root canals. Journal of Applied Oral Science. v.21, n.1, p.25-31, 2013. Disponível em: https://doi.org/10.1590/1678-7757201302129.

Mahboubi, M. Zingiber officinale Rosc. essential oil, a review on its composition and bioactivity. Clinical Phytoscience. v.5, n.1, p.1–12, 2019. Disponível em: https://doi.org/10.1186/s40816-018-0097-4.

Mahyari, S. et al. Evaluation of the efficacy of a polyherbal mouthwash containing Zingiber officinale, Rosmarinus officinalis and Calendula officinalis extracts in patients with gingivitis: A randomized double-blind placebo-controlled trial. Complementary Therapies in Clinical Practice. v.22, p.93–98, 2016. Disponível em: https://doi.org/10.1016/j.ctcp.2015.12.001.

Menon, P. et al. Effectiveness of ginger on pain following periodontal surgery - A randomized cross-over clinical trial. Journal of Ayurveda and integrative medicine. v.12, n.1, p.65–69, 2021. Disponível em: https://doi.org/10.1016/j.jaim.2020.05.003.

Munda, S. et al. Chemical analysis and therapeutic uses of ginger (Zingiber officinale Rosc.) essential oil: a review. Journal of Essential Oil-Bearing Plants. v.21, n.4, p.994–1002, 2018. Disponível em: https://doi.org/10.1080/0972060X.2018.1524794.

Nazir, M. et al. Global Prevalence of Periodontal Disease and Lack of Its Surveillance. The Scientific World Journal. v.2020, p.2146160, 2020. Disponível em: https://doi.org/10.1155/2020/2146160.

Rahman, B. et al. Dysbiosis of the Subgingival Microbiome and Relation to Periodontal Disease in Association with Obesity and Overweight. Nutrients. v.15, n.4, p.826, 2023. Disponível em: https://doi.org/10.3390/nu15040826.

Reynolds, I.; Duane, B. Periodontal disease has an impact on patients' quality of life. Evidence-Based Dentistry. v.19, n.1, p.14–15, 2018. Disponível em: https://doi.org/10.1038/sj.ebd.6401287.

Sahoo, M. et al. Synergistic action of 6-gingerol as an adjuvant to colistin for susceptibility enhancement in multidrug-resistant Klebsiella pneumoniae isolates. RSC advances. v.14, n.11, p.7779–7785, 2024. Disponível em: https://doi.org/10.1039/d3ra07835c.

Sanz, M. et al. European workshop in periodontal health and cardiovascular disease—scientific evidence on the association between periodontal and cardiovascular diseases: a review of the literature. European Heart Journal Supplements. v.12 suppl. B, p.B3–B12, 2010. Disponível em: https://doi.org/10.1093/eurheartj/suq003.

Silva, F. T. D. et al. Action of ginger essential oil (Zingiber officinale) encapsulated in proteins ultrafine fibers on the antimicrobial control in situ. International Journal of Biological Macromolecules. 118(Pt A), p.107–115, 2018. Disponível em: https://doi.org/10.1016/j.ijbiomac.2018.06.079.

Souto, R. et al. Prevalence of "non-oral" pathogenic bacteria in subgingival biofilm of subjects with chronic periodontitis. Brazilian Journal of Microbiology, v.37, n.3, p.208–215, 2006. Disponível em: https://doi.org/10.1590/S1517-83822006000300002.

Veras, E. L. et al. Newly identified pathogens in periodontitis: evidence from an association and an elimination study. Journal of Oral Microbiology. v.15, n.1, p.2213111, 2023. Disponível em: https://doi.org/10.1080/20002297.2023.2213111.

Wang, X. et al. Antibacterial Activity and Mechanism of Ginger Essential Oil against Escherichia coli and Staphylococcus aureus. Molecules. v.25, n.17, p.3955, 2020. Disponível em: https://doi.org/10.3390/molecules25173955.

Wan-Nadilah, W. A. et al. A review of medicinal plants and daily foods used in Southeast Asia possessing antidiabetic activity. Journal of Agrobiotechnology. v.10, p.17–35, 2019.

Yousfi, F. et al. Phytochemical screening and evaluation of the antioxidant and antibacterial potential of Zingiber officinale extracts. South African Journal of Botani. v.142, p.433–440, 2021. Disponível em: https://doi.org/10.1016/j.sajb.2021.07.010.

Publicado

2024-11-13

Cómo citar

Silva, A. R. J. da, & Maria Helena Chaves de Vasconcelos Catão. (2024). ATIVIDADE ANTIMICROBIANA DO Zingiber officinale SOBRE DOIS PERIODONTOPATÓGENOS EMERGENTES: UMA REVISÃO DE LITERATURA. Revista Multidisciplinar Do Nordeste Mineiro, 12(2). https://doi.org/10.61164/rmnm.v12i2.3200

Artículos más leídos del mismo autor/a