MICROBIOTA INTESTINAL NA FISIOPATOLOGIA DA DEPRESSÃO: INFLUÊNCIAS E MECANISMOS
DOI:
https://doi.org/10.61164/rmnm.v12i4.3202Keywords:
Eixo encéfalo-intestino; Interações entre Hospedeiro e Microrganismos; Microbiota; Transtorno depressivo.Abstract
Abstract
Introduction: Depression impairs patients' quality of life, affecting approximately 300 million people worldwide. It requires qualified therapeutic management, however, treatment often encounters refractoriness. In recent decades, the influence of the gut microbiome on the disorder's pathophysiology has been discovered, which may indicate paths for new therapeutic approaches. Objective: To determine whether the gut microbiome influences the pathophysiology of depression and what mechanisms are involved. Methodology: This is an integrative literature review, conducted in six phases, in which Health Sciences Descriptors were combined as follows: <<Depression AND Physiopathology AND "Gastrointestinal Microbiome" AND "Brain-Gut Axis">>. This strategy was used in the databases U.S. National Library of Medicine and the National Institutes Health (PubMed), Biblioteca Virtual em Saúde (BVS), ProQuest Central (ProQuest), Dimensions, and OpenAlex, where a total of 358 articles were eligible, of which 15 were selected for this research. Results: Of the 15 studies analyzed, 100% indicated that the microbiota influences the pathophysiology of depression, pointing to seven main mechanisms of influence, with the hypothalamic-pituitary-adrenal (HPA) axis and stress being the most cited among them. Conclusion: The gut microbiota seems to have a significant influence on the pathophysiology of depression, opening new perspectives for therapeutic approaches, suggesting that modulating this microbiota could be a promising strategy in the treatment of this disorder. However, further studies are needed to deepen the understanding of this relationship and validate new approaches.
Key words: Brain-Gut Axis; Host Microbial Interactions; Microbiota; Depressive Disorder.
References
AMERICAN PSYCHIATRIC ASSOCIATION. Manual Diagnóstico e Estatístico dos Transtornos Mentais: DSM-5-TR. 5. ed. Porto Alegre: Artmed, 2023.
ARNETH, B. M. Gut–brain axis biochemical signalling from the gastrointestinal tract to the central nervous system: gut dysbiosis and altered brain function. Postgraduate Medical Journal, v. 94, n. 1114, p. 446-452, 2018.
CENIT, M. C.; SANZ, Y.; CODOÑER-FRANCH, P. Influence of gut microbiota on neuropsychiatric disorders. World Journal of Gastroenterology, v. 23, n. 30, p. 5486, 2017.
CHANG, L.; WEI, Y.; HASHIMOTO, K. Brain–gut–microbiota axis in depression: A historical overview and future directions. Brain Research Bulletin, v. 182, p. 44-56, 2022.
CHEN, Y. et al. Assessing the effect of interaction between C-reactive protein and gut microbiome on the risks of anxiety and depression. Molecular Brain, v. 14, p. 1-8, 2021.
CHEN, Z. et al. Comparative metaproteomics analysis shows altered fecal microbiota signatures in patients with major depressive disorder. Neuroreport, v. 29, n. 5, p. 417-425, 2018.
COLLINS, S. M.; KASSAM, Z.; BERCIK, P. The adoptive transfer of behavioral phenotype via the intestinal microbiota: experimental evidence and clinical implications. Current Opinion in Microbiology, v. 16, n. 3, p. 240-245, 2013.
DA SILVA, B. M. F. et al. Associação da microbiota intestinal com o transtorno da ansiedade e depressão. Research, Society and Development, v. 10, n. 4, p. e45210414316-e45210414316, 2021.
DE SOUSA, M. N. A.; BEZERRA, A. L. D.; DO EGYPTO, I. A. S. Trilhando o caminho do conhecimento: o método de revisão integrativa para análise e síntese da literatura científica. Observatorio de La Economía Latinoamericana, v. 21, n. 10, p. 18448-18483, 2023.
FARAJ, LT Janine; TAKANTI, LT Varun; TAVAKOLI, Hamid R. The gut-brain axis: Literature overview and psychiatric applications. Federal Practitioner, v. 38, n. 8, p. 356, 2021.
FIM, G. M. et al. Análise comparativa do eixo intestino-cérebro: relação entre disbiose e depressão. Brazilian Journal of Implantology and Health Sciences, v. 5, n. 5, p. 704-717, 2023.
FLUX, M. C.; LOWRY, C. A. Finding intestinal fortitude: Integrating the microbiome into a holistic view of depression mechanisms, treatment, and resilience. Neurobiology of Disease, v. 135, p. 104578, 2020.
FRIED, S. et al. Interactions between the microbiota and enteric nervous system during gut-brain disorders. Neuropharmacology, v. 197, p. 108721, 2021.
HALVERSON, T.; ALAGIAKRISHNAN, K. Gut microbes in neurocognitive and mental health disorders. Annals of Medicine, v. 52, n. 8, p. 423-443, 2020.
HOBAN, A. E. et al. Behavioural and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat. Neuroscience, v. 339, p. 463-477, 2016.
JOHNSTON, J. N. et al. Inflammation, stress and depression: an exploration of ketamine’s therapeutic profile. Drug Discovery Today, v. 28, n. 4, p. 103518, 2023.
KELLY, J. R. et al. Brain-gut-microbiota axis: challenges for translation in psychiatry. Annals of Epidemiology, v. 26, n. 5, p. 366-372, 2016.
KELLY, J. R. et al. Transferring the blues: depression-associated gut microbiota induces neurobehavioural changes in the rat. Journal of Psychiatric Research, v. 82, p. 109-118, 2016.
KNUESEL, T.; MOHAJERI, M. H. The role of the gut microbiota in the development and progression of major depressive and bipolar disorder. Nutrients, v. 14, n. 1, p. 37, 2021.
LAI, W. et al. Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in major depressive disorder patients. Psychological Medicine, v. 51, n. 1, p. 90-101, 2021.
LIANG, S. et al. Recognizing depression from the microbiota–gut–brain axis. International Journal of Molecular Sciences, v. 19, n. 6, p. 1592, 2018.
MESSAOUDI, M. et al. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. British Journal of Nutrition, v. 105, n. 5, p. 755-764, 2011.
MŁYNARSKA, E. et al. The role of the microbiome-brain-gut axis in the pathogenesis of depressive disorder. Nutrients, v. 14, n. 9, p. 1921, 2022.
ORGANIZAÇÃO PAN-AMERICANA DA SAÚDE. Depressão. Brasília, DF: OPAS, 2017.
OUZZANI, M. et al. Rayyan – a web and mobile app for systematic reviews. Systematic reviews, v. 5, p. 1-10, 2016.
PAGE, M. J. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Bmj, v. 372, 2021.
PEIRCE, J. M.; ALVIÑA, K. The role of inflammation and the gut microbiome in depression and anxiety. Journal of Neuroscience Research, v. 97, n. 10, p. 1223-1241, 2019.
REYES-MARTÍNEZ, S. et al. Neuroinflammation, Microbiota-Gut-Brain Axis, and Depression: The Vicious Circle. Journal of Integrative Neuroscience, v. 22, n. 3, p. 65, 2023.
RIEDER, R. et al. Microbes and mental health: A review. Brain, Behavior, and Immunity, v. 66, p. 9-17, 2017.
SARIN, L. M.; DEL PORTO, J. A. Antipsicóticos atípicos na depressão
refratária. Jornal Brasileiro de Psiquiatria, v. 58, p. 73-78, 2009.
ȘCHIOPU, C. G. et al. Functional gastrointestinal disorders with psychiatric symptoms: involvement of the microbiome–gut–brain axis in the pathophysiology and case management. Microorganisms, v. 10, n. 11, p. 2199, 2022.
SEADY, M. P. Investigação do papel da curcumina na neuroinflamação induzida por lipopolissacarídeo. 2023.
SHERWIN, E. et al. A gut (microbiome) feeling about the brain. Current Opinion in Gastroenterology, v. 32, n. 2, p. 96-102, 2016.
SLYEPCHENKO, A. et al. Gut microbiota, bacterial translocation, and interactions with diet: pathophysiological links between major depressive disorder and non-communicable medical comorbidities. Psychotherapy and Psychosomatics, v. 86, n. 1, p. 31-46, 2016.
ZHANG, J. et al. A key role of the subdiaphragmatic vagus nerve in the depression-like phenotype and abnormal composition of gut microbiota in mice after lipopolysaccharide administration. Translational Psychiatry, v. 10, n. 1, p. 186, 2020.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Revista Multidisciplinar do Nordeste Mineiro
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
