PREDICTIVE EVALUATION OF THE TOXICITY AND ADVERSE EFFECTS OF PLANTANONES A-D
DOI:
https://doi.org/10.61164/rmnm.v6i1.2529Keywords:
Hosta plantaginea; Anti-inflammatories; Dosage; Rats.Abstract
Chronic prostatitis, a common condition in urology, is responsible for inflammation of the prostate tissues and can be aggravated by factors such as oxidative stress and inflammatory responses. Conventional treatments, such as anti-inflammatories, hormone therapies, and surgery, have shown limited efficacy, so new treatment methods are needed. Components of the herb Hosta plantaginea may offer new therapeutic approaches due to their anti-inflammatory, antibacterial, and antioxidant properties. Studies on obtaining new pharmacological compounds derived from H. plantaginea have obtained plantanones A-D, which belong to the flavonoid class and have anti-inflammatory activities. In this sense, the study aims to predictively evaluate the toxicological safety of plantanones in rats, to understand their adverse effects as drugs. The analysis was based on the GUSAR© and ProTox© tools to assess toxicity (LD50) through the routes of administration (intraperitoneal, intravenous, oral, and subcutaneous) and the toxicological endpoints in rats. GraphPad Prism® software was also used for statistical validation using the one-way ANOVA and normality tests. The results indicate that plantanones are possibly dangerous if ingested, that they can generate toxic effects via the IP and IV routes, and that plantanones A-C cause immunotoxicity. Further studies evaluating the toxicity of plantanones in organs and in vivo and in vitro tests could be carried out to corroborate the results presented.
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