A TOXICOLOGIA DO PARACETAMOL PARA GESTANTES
DOI:
https://doi.org/10.61164/rmnm.v13i1.1929Keywords:
Paracetamol, autismo, gestação, acetaminofenoAbstract
The study investigated the relationship between the use of paracetamol during pregnancy and potential impacts such as autism and immunological dysfunctions in the child. Evidence suggests a correlation between prenatal exposure to paracetamol and an increased risk of autism and neuropsychiatric disorders. Additionally, there are indications of a negative influence of paracetamol on the child's immune system. The research was conducted using sources from SCIELO and LILACS with a temporal scope between 2013 and 2023. The complexity of these relationships underscores the need for caution in paracetamol use during pregnancy, emphasizing the importance of ongoing research to clarify risks and provide clear guidance to pregnant individuals and healthcare professionals. This study offers an objective approach to the consequences of inappropriate paracetamol use during pregnancy, promoting awareness and careful medication use, with a preference for alternatives and minimizing exposure whenever possible.
References
BRANDLISTUEN, Ragnhild Eek et al. *Paracetamol use in pregnancy and child outcomes: analysis of observational studies.* 2013.
KRISTENSEN, DM et al. *Paracetamol use in pregnancy: effects on fetal germ cell development.* 2016.
NOURJAH, P. et al. *Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta-analysis.* 2015.
EMAUS, MJ et al. *Prenatal paracetamol exposure and child neurodevelopment: a review.* 2019.
ANDRADE, Chittaranjan. Use of acetaminophen (paracetamol) during pregnancy and the risk of autism spectrum disorder in the offspring. *The Journal of Clinical Psychiatry*, v. 77, n. 2, p. 329, 2016. DOI: https://doi.org/10.4088/JCP.16f10637
AVELLA-GARCIA, Claudia B. et al. Acetaminophen use in pregnancy and neurodevelopment: attention function and autism spectrum symptoms. *International Journal of Epidemiology*, v. 45, n. 6, p. 1987-1996, 2016.
BAUER, A.Z. et al. Paracetamol use during pregnancy — a call for precautionary action. *Nature Reviews Endocrinology*, v. 17, p. 757–766, 2021. DOI: 10.1038/s41574-021-00553-7. DOI: https://doi.org/10.1038/s41574-021-00553-7
BAUER, Ann Z et al. Prenatal paracetamol exposure and child neurodevelopment: A review. *Hormones and Behavior*, v. 101, p. 125-147, 2018. DOI: 10.1016/j.yhbeh.2018.01.003. DOI: https://doi.org/10.1016/j.yhbeh.2018.01.003
BECKER, Kevin G.; SCHULTZ, Stephen T. Similarities in features of autism and asthma and a possible link to acetaminophen use. *Medical Hypotheses*, v. 74, n. 1, p. 7-11, 2010. DOI: https://doi.org/10.1016/j.mehy.2009.08.033
CANNELL, JJ. Paracetamol, oxidative stress, vitamin D and autism spectrum disorders. *International Journal of Epidemiology*, v. 43, n. 3, p. 974-975, 2014. DOI: 10.1093/ije/dyu004. DOI: https://doi.org/10.1093/ije/dyu004
FAYS, L. et al. Use of paracetamol during pregnancy and child neurological development. *Developmental Medicine and Child Neurology*, v. 57, n. 8, p. 718-724, 2015. DOI: 10.1111/dmcn.12745. DOI: https://doi.org/10.1111/dmcn.12745
FREITAS, Jhonattas Alexandre Barbosa et al. Medicamentos isentos de prescrição: perfil de consumo e os riscos tóxicos do paracetamol. *Revinter*, v. 10, n. 3, p. 134-154, 2017. DOI: https://doi.org/10.22280/revintervol10ed3.337
LIPIEC, et al. The association between paracetamol use and the risk of asthma, rhinitis and eczema in the Polish population. *Annals of Agricultural and Environmental Medicine*, v. 25, n. 3, DOI: https://doi.org/10.26444/aaem/86336
LO, P. et al. Risk of childhood asthma exacerbation associated with non-steroidal anti-inflammatory drugs. *Medicine*, v. 95, n. 41, 2016. Disponível em: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072955/>. DOI: https://doi.org/10.1097/MD.0000000000005109
MELO, A. J. M. et al. Acetaminofeno na gravidez e o risco de transtorno do espectro autista em crianças. *Journal of Medicine and Health Promotion*, v. 2, p. 481-492, 2017.
SORDILLO, et al. Prenatal and Infant Exposure to Acetaminophen and Ibuprofen and the Risk for Wheeze and Asthma in Children. *Journal of Allergy and Clinical Immunology*, v. 2, n. 135, p. 441-448, 2015. Disponível em: <https://www.sciencedirect.com/science/article/abs/pii/S0091674914012779>. DOI: https://doi.org/10.1016/j.jaci.2014.07.065
VAN DEN, D. et al. Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model. *Science Translational Medicine*, v. 7, n. 288, 2015. DOI: 10.1126/scitranslmed.aaa4097. DOI: https://doi.org/10.1126/scitranslmed.aaa4097
HOLM, Jacob Bak, et al. A exposição intrauterina ao paracetamol e à anilina prejudica o desenvolvimento reprodutivo feminino, reduzindo as reservas foliculares e a fertilidade. *Ciências Toxicológicas*, v. 150, n. 1, 2016, p. 178-188.
SILVA, Mariana de Souza. Associação entre paracetamol e asma na infância: uma revisão de literatura. 2022.
CASTRO, Caroline Tianeze de. Uso de paracetamol durante a gestação e desenvolvimento de desfechos perinatais. 2021.
VIEIRA, Ariane Lombarde; FRANÇA, Gustavo Galvão. As consequências no consumo indiscriminado do paracetamol e orientação farmacêutica à promoção ao uso racional. *Revista Acadêmica Oswaldo Cruz*, São Paulo, v. 6, n. 6, p. 1-12, 2015.
ARAÚJO, Cristina Abreu de. Efeitos dos pré-tratamentos com paracetamol e ibuprofeno na fertilidade. 2019. Tese de Doutorado, Brasil
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