THERAPEUTIC ACTION OF COMPOUNDS PRESENT IN MORUS NIGRA L. IN INSULIN RESISTANCE
DOI:
https://doi.org/10.61164/rmnm.v13i1.1935Keywords:
Mulberry Extracts, Morus Nigra L., Insulin ResistanceAbstract
Morus nigra L., popularly known as black mulberry, has aroused interest due to its potential therapeutic benefits, especially in the context of insulin resistance. Several compounds present in this plant have been studied, revealing properties that may contribute to the improvement of insulin sensitivity. Among these compounds, flavonoids, anthocyanins, and polyphenols stand out, which have antioxidant and anti-inflammatory properties. The therapeutic action of these components seems to modulate metabolic pathways related to glucose control and lipid metabolism, promoting a more favorable environment for insulin sensitivity. The general objective of the present study was to discuss the therapeutic action of compounds present in Morus Nigra L. in insulin resistance. The present study is an integrative review and is considered an important tool in the health area, as it synthesizes the available research on a given topic and directs the practice based on scientific knowledge. It is a method that, through the synthesis of knowledge and incorporation of results, results in the reduction of biases and errors. Based on the guidelines and standards of the Brazilian Association of Standards and Techniques. The insertion of the descriptors in the databases resulted in the location of 102 productions, 53 in the VHL and 49 in the PUBMED. Therefore, Morus nigra L. stands out as a potential source of compounds with therapeutic action on insulin resistance, offering a promising approach in the prevention and treatment of type 2 diabetes and its complications. With their effects on glycemic regulation, lipid metabolism, gut microbiota, and gut barrier integrity, the compounds present in black mulberry represent a valuable prospect for improving the health and quality of life of individuals affected by this metabolic condition.
References
CHEN, H. et al. Propriedades Antiinflamatórias e Antinociceptivas dos Flavonoides dos Frutos da Amoreira Preta (Morus nigra L). PLos UM, v. 11, n. 4, p. 1-14, 2016. Disponível em: 10.1371/ Journal. pone.0153080. Acesso em: 30 out. 2023.
GONÇALVES, J. Como escrever um artigo de revisão integrativa de literatura. Revista JRG de Estudos Acadêmicos [online] v. 2, n. 5, p. 29-55, 2019. Disponível em: http://www.revistajrg.com/index.php/jrg/article/view/122/201. Acesso em: 22 out. 2023.
HUANG, H.; OU, T.; WANG, C. Amoreira e seus bioativo composto, os efeitos da quimioprevenção e moleculares mecanismos in vitro e in vivo. Revista de Medicina Tradicional e Complementar, v. 13, n. 1, p. 1-9, 2013. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924983/. Acesso em: 29 out. 2023.
HUSSAIN, F. et al. Potencial fito farmacológico de diferentes espécies de Morus alba e seus fitoquímicos bioativos: Uma revisão. Asiático Pac. J. Trop. Biomédico, v. 7, n. 10, p. 950-956, 2017. Disponível em: http://dx.doi.org/10.1016/j.apjtb.2017.09.015. Acesso em: 30 out. 2023. DOI: https://doi.org/10.1016/j.apjtb.2017.09.015
JAN, B. et al. Constituintes nutricionais da amoreira e suas potenciais aplicações nos alimentos e produtos farmacêuticos: uma revisão. Journal saudita de Ciências Biológicas, v. 28, p. 3909-3921, 2021. Disponível em: https://doi.org/10.1016/j.sjbs.2021.03.056. Acesso em: 30 out. 2023. DOI: https://doi.org/10.1016/j.sjbs.2021.03.056
JÚNIOR, I. et al. Morus nigra brasileiro atenua hiperglicemia, dislipidemia e status pró-oxidante em ratos diabéticos induzidos por aloxana. Hindawi, v. 1, p. 1-11, 2017. Disponível em: https://doi.org/10.1155/2017/5275813. Acesso em: 01 nov. 2023. DOI: https://doi.org/10.1155/2017/5275813
KRISHMA, H. et al. Características morfológicas e antioxidantes de genótipos de amoreira (Morus spp.). Journal da Sociedade Saudita de Ciências Agrícolas, v. 19, p. 136-145, 2020. Disponível em: https://doi.org/10.1016/j.jssas.2018.08.002. Acesso em: 31 out. 2023. DOI: https://doi.org/10.1016/j.jssas.2018.08.002
TANG, P. et al. Atividade antidiabética do extrato de galhos de Morus nigra L. através da ativação da via AMPK/PKC em camundongos. Journal de Alimentos funcionais, v. 99, p. 1-12, 2022. Disponível em: https://doi.org/10.1016/j.jff.2022.105358. Acesso em: 30 out. 2023. DOI: https://doi.org/10.1016/j.jff.2022.105358
YADAV, S. et al. Notas etnobotânicas atualizadas, fitoquímica e fitofarmacologia de plantas pertencentes ao gênero Morus (Família: Moraceae). Fitomedicina Plus, v. 2, p. 1-13, 2022. Disponível em: https://doi.org/10.1016/j.phyplu.2021.100120. Acesso em: 30 out. 2023. DOI: https://doi.org/10.1016/j.phyplu.2021.100120
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Revista Multidisciplinar do Nordeste Mineiro
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
